Molecular mechanisms of glutamate toxicity in Parkinson's disease
J Wang, F Wang, D Mai, S Qu - Frontiers in neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …
features of which include the presence of Lewy bodies and the neurodegeneration of …
Metabotropic glutamate receptors and neurodegenerative diseases
Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …
Antisense oligonucleotide therapy for spinocerebellar ataxia type 2
DR Scoles, P Meera, MD Schneider, S Paul… - Nature, 2017 - nature.com
There are no disease-modifying treatments for adult human neurodegenerative diseases.
Here we test RNA-targeted therapies in two mouse models of spinocerebellar ataxia type 2 …
Here we test RNA-targeted therapies in two mouse models of spinocerebellar ataxia type 2 …
Calcium-activated potassium channels
Calcium-activated potassium channels are fundamental regulators of neuronal excitability,
participating in interspike interval and spike-frequency adaptation. For large-conductance …
participating in interspike interval and spike-frequency adaptation. For large-conductance …
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
R Anwyl - Brain research reviews, 1999 - Elsevier
Electrophysiological research on mGluRs is now very extensive, and it is clear that activation
of mGluRs results in a large number of diverse cellular actions. Studies of mGluRs and on …
of mGluRs results in a large number of diverse cellular actions. Studies of mGluRs and on …
Burst firing in midbrain dopaminergic neurons
PG Overton, D Clark - Brain Research Reviews, 1997 - Elsevier
Midbrain dopaminergic (DA) neurons fire bursts of activity in response to sensory stimuli,
including those associated with primary reward. They are therefore conditional bursters–the …
including those associated with primary reward. They are therefore conditional bursters–the …
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function
G Mannaioni, MJ Marino, O Valenti… - Journal of …, 2001 - Soc Neuroscience
The activation of group I metabotropic glutamate receptors (mGluRs) produces a variety of
actions that lead to alterations in excitability and synaptic transmission in the CA1 region of …
actions that lead to alterations in excitability and synaptic transmission in the CA1 region of …
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
SH Li, KS Abd-Elrahman, SSG Ferguson - Pharmacology & therapeutics, 2022 - Elsevier
Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all
aspects of neuronal function. Disruption of normal glutamate transmission has been …
aspects of neuronal function. Disruption of normal glutamate transmission has been …
Involvement of hippocampal synaptic plasticity in age-related memory decline
TC Foster - Brain research reviews, 1999 - Elsevier
This article examines the functional significance of Ca2+-dependent synaptic plasticity in
relation to compromised memory function during aging. Research characterizing an age …
relation to compromised memory function during aging. Research characterizing an age …
Ion channels in presynaptic nerve terminals and control of transmitter release
A Meir, S Ginsburg, A Butkevich… - Physiological …, 1999 - journals.physiology.org
The primary function of the presynaptic nerve terminal is to release transmitter quanta and
thus activate the postsynaptic target cell. In almost every step leading to the release of …
thus activate the postsynaptic target cell. In almost every step leading to the release of …