Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Ample interest has been evoked in using placental angiogenesis as a target for the
development of diagnosis tools and potential therapeutics for pregnancy complications …

Hemochorial placentation is orchestrated through highly regulated temporal and spatial
decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell …

The prevalence of obesity during pregnancy continues to increase at alarming rates. This is
concerning as in addition to immediate impacts on maternal wellbeing, obesity during …

Complications of pregnancy remain key drivers of morbidity and mortality, affecting the
health of both the mother and her offspring in the short and long term. There is lack of …

Background Preeclampsia (PE) is a life-threatening hypertensive pathology of pregnancy
affecting 3–5% of all pregnancies. To date, PE has no cure, early detection markers, or …

Intrauterine growth restriction (IUGR) is one of the most common concerns in human
obstetrics and domestic animal production. It is usually caused by placental insufficiency …

The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging
from humoral to mechanical forces. The gatekeeper regulating many of these factors is the …

Placental dysfunction underlies major obstetric diseases such as pre-eclampsia and fetal
growth restriction (FGR). Whilst there has been a little progress in prophylaxis, there are still …

Elevated maternal testosterone levels are shown to cause fetal growth restriction, eventually
culminating in sex-specific adult-onset hypertension that is more pronounced in males than …