The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
The role of nitric oxide in cancer: master regulator or NOt?
FH Khan, E Dervan, DD Bhattacharyya… - International journal of …, 2020 - mdpi.com
Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …
depending on the source and concentration of NO. In this review, we discuss the …
RHINO directs MMEJ to repair DNA breaks in mitosis
Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …
Kinetics and fidelity of the repair of Cas9-induced double-strand DNA breaks
EK Brinkman, T Chen, M de Haas, HA Holland… - Molecular cell, 2018 - cell.com
The RNA-guided DNA endonuclease Cas9 is a powerful tool for genome editing. Little is
known about the kinetics and fidelity of the double-strand break (DSB) repair process that …
known about the kinetics and fidelity of the double-strand break (DSB) repair process that …
Microhomology-mediated end joining: Good, bad and ugly
JH Seol, EY Shim, SE Lee - Mutation Research/Fundamental and …, 2018 - Elsevier
DNA double-strand breaks (DSBs) are induced by a variety of genotoxic agents, including
ionizing radiation and chemotherapy drugs for treating cancers. The elimination of DSBs …
ionizing radiation and chemotherapy drugs for treating cancers. The elimination of DSBs …
Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
S Wimberger, N Akrap, M Firth, J Brengdahl… - Nature …, 2023 - nature.com
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical
research and offers potential cures for genetic diseases. Despite rapid progress, low …
research and offers potential cures for genetic diseases. Despite rapid progress, low …
Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair …
G Iliakis, T Murmann, A Soni - Mutation Research/Genetic Toxicology and …, 2015 - Elsevier
DNA double strand breaks (DSB) are the most deleterious lesions for the integrity of the
genome, as their misrepair can lead to the formation of chromosome translocations. Cells …
genome, as their misrepair can lead to the formation of chromosome translocations. Cells …
Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma
Y Hu, J Lin, H Fang, J Fang, C Li, W Chen, S Liu… - Leukemia, 2018 - nature.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved
long non-coding RNA (lncRNA). Overexpression of MALAT1 has been demonstrated to …
long non-coding RNA (lncRNA). Overexpression of MALAT1 has been demonstrated to …
Precise therapeutic gene correction by a simple nuclease-induced double-stranded break
Current programmable nuclease-based methods (for example, CRISPR–Cas9) for the
precise correction of a disease-causing genetic mutation harness the homology-directed …
precise correction of a disease-causing genetic mutation harness the homology-directed …