Mast cells and the gut-liver Axis: Implications for liver disease progression and therapy

B Nair, AJ Kamath, V Tergaonkar, G Sethi, LR Nath - Life Sciences, 2024 - Elsevier
The role of mast cells, traditionally recognized for their involvement in immediate
hypersensitivity reactions, has garnered significant attention in liver diseases. Studies have …

Allergenic protein-induced type I hypersensitivity models: a review

Y Feng, L Xu, J Zhang, J Bin, X Pang, S He… - Frontiers in …, 2024 - frontiersin.org
Context Type I hypersensitivity affects approximately one-third of the global population. As
the pathophysiology underlying the development of type I hypersensitivity (asthma, food …

Kamebakaurin Suppresses Antigen-Induced Mast Cell Activation by Inhibition of FcεRI Signaling Pathway

H Asai, K Kato, M Miyasaka, K Hatsukawa… - … Archives of Allergy and …, 2024 - karger.com
Introduction: Kamebakaurin is an active constituent of both Rabdosia japonica and
Rabdosia excisa, which are utilized in Chinese traditional medicine for improving symptoms …

[HTML][HTML] Anti-Allergic Effects of Lonicera caerulea L. Extract and Cyanidin-3-Glucoside on Degranulation and FcεRI Signaling Pathway of RBL-2H3 Cells

YE Choi, JM Yang, CW Jeong, SH Park, HW Yoo… - Applied Sciences, 2024 - mdpi.com
(i) Background: The increasing prevalence of allergic diseases highlights the need for
effective treatments. Lonicera caerulea fruit has been recognized for its anti-inflammatory …

Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcϵRI Aggregation and Structural Changes

DA Rinaldi, WK Kanagy, HC Kaye, RM Grattan… - bioRxiv, 2023 - biorxiv.org
Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical
components of the innate and adaptive immune systems. FcϵRI mediates the allergic …

[HTML][HTML] Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes

DA Rinaldi, WK Kanagy, HC Kaye, RM Grattan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical
components of the innate and adaptive immune systems. FcεRI mediates the allergic …

Interrogation of the molecular mechanisms that finetune FcεRI signaling and mast cell outcomes

DA Rinaldi - 2023 - digitalrepository.unm.edu
FcεRI is the ITAM receptor primarily responsible for the allergic response and immune
hypersensitivity diseases such as asthma. Regulation of the strength of both FcεRI signaling …