The field of gene therapy is striving more than ever to define a path to the clinic and the
market. Twenty gene therapy products have already been approved and over two thousand …

The first gene therapy clinical trials were initiated more than two decades ago. In the early
days, gene therapy shared the fate of many experimental medicine approaches and was …

Cell-surface CD25 expression is critical for maintaining immune function and homeostasis.
As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and …

Adoptive T-cell therapy can involve donor lymphocyte infusion after allogeneic
hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte …

Adoptive transfer of donor-derived T lymphocytes expressing a safety switch may promote
immune reconstitution in patients undergoing haploidentical hematopoietic stem cell …

Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …

Tumors originate from a number of genetic events that deregulate homeostatic mechanisms
controlling normal cell behavior. The immune system, devoted to patrol the organism against …

While opening new frontiers for the cure of malignant and non-malignant diseases, the
increasing use of cell therapy poses also several new challenges related to the safety of a …

Long-lasting immune protection from pathogens and cancer requires the generation of
memory T cells able to survive long-term. To unravel the immunological requirements for …

Haploidentical hematopoietic stem cell transplantation (HSCT) offers the benefits of rapid
and nearly universal donor availability and has been accepted worldwide as an alternative …