Reactive amino acid side chains play important roles in the binding of peptides to specific
targets. In addition, their reactivity enables selective peptide conjugation and …

The chemical and physical properties of proteins are limited by the 20 canonical amino
acids. Genetic code manipulation allows for the incorporation of noncanonical amino acids …

Engineering of biosynthetic enzymes is increasingly employed to synthesize structural
analogues of antibiotics. Of special interest are nonribosomal peptide synthetases (NRPSs) …

Nonribosomal peptides constitute an important class of natural products that display a wide
range of bioactivities. They are biosynthesized by large assembly lines called nonribosomal …

Nonribosomal peptide synthetases (NRPSs) produce diverse natural products including
siderophores, chelating agents that many pathogenic bacteria produce to survive in low iron …

Nonribosomal peptides (NRPs) have gained attention due to their diverse biological
activities and potential applications in medicine and agriculture. The natural diversity of …

Lipopeptides are an important family of natural products, some of which are clinically used
as antibiotics to treat multidrug-resistant pathogens. Although the lipid moieties play a …

Peptide-based antibiotics (PBAs), including antimicrobial peptides (AMPs) and their
synthetic mimics, have received significant interest due to their diverse and unique …

Highlights•High-yield microbial chassis streamline terpene (skeleton) mining.•Automated
high-throughput workstation expedites terpenoid library construction.•Artificial intelligence …

Nonribosomal peptide synthetases (NRPSs) are sophisticated molecular machines that
biosynthesize peptide drugs. In attempts to generate new bioactive compounds, some parts …