Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Once thought of exclusively as damaging molecules, reactive oxygen species (ROS) are
becoming increasingly appreciated for the role they play in cellular signaling through redox …

Interest in the topic of tumour metabolism has waxed and waned over the past century of
cancer research. The early observations of Warburg and his contemporaries established …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Reactive oxygen species (ROS) are a group of molecules produced in the cell through
metabolism of oxygen. Endogenous ROS such as hydrogen peroxide (H 2 O 2) have long …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

H2O2 production, protection, and signaling actions. Activation of various cell surface
receptors activates Nox situated either in the plasma membrane or in the membrane of …