Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …

For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …

The lysosome is a degradative organelle, and its fusion with other organelles is strictly
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …

Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and
macromolecules via deformation of the membrane and generation of membrane-bound …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

Macroautophagy is an evolutionarily conserved catabolic mechanism that delivers
intracellular constituents to lysosomes using autophagosomes. To achieve degradation …

Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

Autophagy is an intracellular degradation pathway essential for cellular and energy
homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles …

Platelets play a central role in the arrest of bleeding after damage to a blood vessel and in
the development of thrombosis. Platelets rapidly respond after interaction with sub …