Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs

L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

[PDF][PDF] A review on marketed Carica papaya leaf extract (CPLE) supplements for the treatment of dengue fever with thrombocytopenia and its drawback

S Mandal, DV Jaiswal, K Shiva - International Journal of …, 2020 - researchgate.net
Aim: In this review, there is detail description of the supplements present in the market for the
treatment of dengue a deadly viral disease. According to WHO survey, 40% of the …

Micronization in food processing: A comprehensive review of mechanistic approach, physicochemical, functional properties and self-stability of micronized food …

A Dhiman, PK Prabhakar - Journal of Food Engineering, 2021 - Elsevier
Micronization is a mechanical and high shearing operation to downsize the particles of food
material to the micron range. Conventionally micronization techniques were employed in …

Nanonization techniques to overcome poor water-solubility with drugs

FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Most drugs used in therapy have low water-solubility, a factor that could reduce
their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical …

Supercritical fluid technologies for the incorporation of synthetic and natural active compounds into materials for drug formulation and delivery

KA Kravanja, M Finšgar, Ž Knez, M Knez Marevci - Pharmaceutics, 2022 - mdpi.com
Various active compounds isolated from natural sources exhibit remarkable benefits, making
them attractive for pharmaceutical and biomedical applications, such as antioxidant …

Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Measuring solubility of a chemotherapy-anti cancer drug (busulfan) in supercritical carbon dioxide

M Pishnamazi, S Zabihi, S Jamshidian… - Journal of Molecular …, 2020 - Elsevier
In the current study, the solubility of busulfan which is a chemotherapy drug for treating
chronic myelogenous leukemia (CML) is measured in supercritical carbon dioxide (SC-CO …

Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them

A Sosnik, R Augustine - Advanced drug delivery reviews, 2016 - Elsevier
Abstract Development of novel drug delivery systems (DDS) represents a promising
opportunity to overcome the various bottlenecks associated with the chronic antiretroviral …

Exploring the temperature-dependent proportions of lidocaine conformers equilibria in supercritical carbon dioxide via NOESY

IA Khodov, KV Belov, VV Sobornova, AA Dyshin… - Journal of Molecular …, 2023 - Elsevier
This research determined the proportions of lidocaine conformer groups in a supercritical
carbon dioxide environment at constant pressures (10, 20 and 30 MPa) and temperatures of …

Bicalutamide anticancer activity enhancement by formulation of soluble inclusion complexes with cyclodextrins

F De Gaetano, MC Cristiano, D Paolino, C Celesti… - Biomolecules, 2022 - mdpi.com
Bicalutamide (BCL) is a nonsteroidal antiandrogen drug that represents an alternative to
castration in the treatment of prostate cancer, due to its relatively long half-life and tolerable …