Steering self-organisation through confinement

NAM Araújo, LMC Janssen, T Barois, G Boffetta… - Soft Matter, 2023 - pubs.rsc.org
Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns
from the interaction of smaller individual units. Examples are found across many scales in …

Cell motility in confluent tissues induced by substrate disorder

DEP Pinto, MMT da Gama, NAM Araújo - Physical Review Research, 2022 - APS
In vivo and in vitro cells rely on the support of an underlying biocompatible substrate, such
as the extracellular matrix or a culture substrate, to spread and proliferate. The mechanical …

Effect of anisotropy on the formation of active particle films

TC Rebocho, M Tasinkevych, CS Dias - Physical Review E, 2022 - APS
Active colloids belong to a class of nonequilibrium systems where energy uptake,
conversion, and dissipation occur at the level of individual colloidal particles, which can lead …

Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells

HPM Melo, FR Maia, AS Nunes, RL Reis… - Scientific Reports, 2021 - nature.com
The collective dynamics of cells on surfaces and interfaces poses technological and
theoretical challenges in the study of morphogenesis, tissue engineering, and cancer …

Model for active particles confined in a two-state micropattern

FMR Safara, HPM Melo, MMT da Gama, NAM Araújo - Soft Matter, 2022 - pubs.rsc.org
We propose a model, based on active Brownian particles, for the dynamics of cells confined
in a two-state micropattern, composed of two rectangular boxes connected by a bridge, and …

Minimal model for active particles confined in a two-state micropattern

FMR Safara, HP Melo, MM da Gama… - arXiv preprint arXiv …, 2022 - arxiv.org
We propose a minimal model, based on active Brownian particles, for the dynamics of cells
confined in a two-state micropattern, composed of two rectangular boxes connected by a …

Substrate disorder promotes cell motility in confluent tissues

DEP Pinto, MMT da Gama, NAM Araujo - arXiv preprint arXiv:2111.01829, 2021 - arxiv.org
In vivo and in vitro cells rely on the support of an underlying biocompatible substrate, such
as the extracellular matrix or a culture substrate, to spread and proliferate. The mechanical …

Collective dynamics of flexible active particles on substrates: from cells to tissues

D Estevão Pereira Pinto - 2022 - repositorio.ul.pt
We study the effects of disorder in epithelial confluent tissues through the Voronoi model for
dense tissues. The modeling of epithelial tissues relies on three different mechanisms: cell …