The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical
and functional associations with sensory afferent neurons. We reveal that epidermal nerve …

Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ) is
required for differentiation of skin-recruited CD8+ T cell effectors into epidermal resident …

Massively parallel reporter assays (MPRAs) test the capacity of putative gene regulatory
elements to drive transcription on a genome-wide scale. Most gene regulatory activity occurs …

Gene expression programs are specified by higher-order chromatin structure and enhancer-
promoter loops (EPLs). T regulatory cell (Treg) identity is dominantly specified by the …

Transcriptional enhancers are critical for development and phenotype evolution and are
often mutated in disease contexts; however, even in well-studied cell types, the sequence …

Cell division is an essential component of B cell differentiation to Ab-secreting plasma cells,
with critical reprogramming occurring during the initial stages of B cell activation. However, a …

The immune system is a complex biological network composed of hierarchically organized
genes, proteins, and cellular components that combat external pathogens and monitor the …

During cellular differentiation chromosome conformation is intricately remodelled to support
the lineage-specific transcriptional programs required for initiating and maintaining lineage …