The generation and maintenance of CD 8+ T cell memory is crucial to long‐term host
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

NK cells are short‐lived innate lymphocytes that can mediate antigen‐independent
responses to infection and cancer. However, studies from the past two decades have shown …

Natural killer (NK) cells are innate lymphocytes that exhibit many features of adaptive
immunity, including clonal proliferation and long-lived memory. Here we demonstrate that …

The highly conserved cellular degradation pathway, macroautophagy, regulates the
homeostasis of organelles and promotes the survival of T lymphocytes. Previous results …

Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity,
such as memory formation. However, the molecular mechanisms by which NK cells persist …

Summary Decreased HIV-specific CD8+ T cell proliferation is a hallmark of chronic infection,
but the mechanisms of decline are unclear. We analyzed gene expression profiles from …

Primary immune responses generate short-term effectors and long-term protective memory
cells. The delineation of the genealogy linking naive, effector, and memory cells has been …

Background The survival of patients with cervical cancer who are treated with cisplatin in
conjunction with the topoisomerase I inhibitor topotecan is enhanced when compared with …

Alternative polyadenylation (APA) is an essential post-transcriptional process that produces
mature mRNA isoforms by regulating the usage of polyadenylation sites (PASs). APA is …