What do drug transporters really do?
SK Nigam - Nature reviews Drug discovery, 2015 - nature.com
Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
Clinical probes and endogenous biomarkers as substrates for transporter drug‐drug interaction evaluation: perspectives from the international transporter consortium
X Chu, M Liao, H Shen, K Yoshida… - Clinical …, 2018 - Wiley Online Library
Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …
substrate drugs and endogenous substances. Investigations to examine their potential …
PBPK models for the prediction of in vivo performance of oral dosage forms
ES Kostewicz, L Aarons, M Bergstrand… - European Journal of …, 2014 - Elsevier
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …
upon numerous factors including the physicochemical properties of the drug, characteristics …
[HTML][HTML] Renal drug transporters and their significance in drug–drug interactions
J Yin, J Wang - Acta Pharmaceutica Sinica B, 2016 - Elsevier
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …
In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development
KLR Brouwer, D Keppler, KA Hoffmaster… - Clinical …, 2013 - Wiley Online Library
This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …
to assess the role of transport proteins in drug/metabolite disposition in humans. The …
The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans
Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans
is important to reduce the risk of failure during drug development. In addition, when …
is important to reduce the risk of failure during drug development. In addition, when …
Protein abundance of clinically relevant drug transporters in the human liver and intestine: a comparative analysis in paired tissue specimens
M Drozdzik, D Busch, J Lapczuk… - Clinical …, 2019 - Wiley Online Library
Bioavailability of orally administered drugs is partly determined by function of drug
transporters in the liver and intestine. Therefore, we explored adenosine triphosphate …
transporters in the liver and intestine. Therefore, we explored adenosine triphosphate …
Transporters in drug development: International transporter consortium update on emerging transporters of clinical importance
MJ Zamek‐Gliszczynski, V Sangha… - Clinical …, 2022 - Wiley Online Library
During its fourth transporter workshop in 2021, the International Transporter Consortium
(ITC) provided updates on emerging clinically relevant transporters for drug development …
(ITC) provided updates on emerging clinically relevant transporters for drug development …
[HTML][HTML] How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Transporters in drug development and clinical pharmacology
KM Giacomini, SM Huang - Clinical Pharmacology & …, 2013 - Wiley Online Library
More than 400 membrane transporters in two major superfamilies—ATP‐binding cassette
(ABC) and solute carrier (SLC)—are annotated in the human genome. Preclinical and …
(ABC) and solute carrier (SLC)—are annotated in the human genome. Preclinical and …