Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Ribonucleases H are enzymes that cleave the RNA of RNA/DNA hybrids that form during
replication and repair and which could lead to DNA instability if they were not processed …

RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …

The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …

To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …

Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at
frequencies of about 2 per kb, which makes them by far the most abundant form of potential …

RNases H are a family of endonucleases that hydrolyze RNA residues in various nucleic
acids. These enzymes are present in all branches of life, and their counterpart domains are …

The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops
from mutations in genes encoding several nucleotide-processing proteins, including RNase …

The information encoded in DNA is influenced by the presence of non-canonical
nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss …

Genome integrity is continuously challenged by the DNA damage that arises during normal
cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme …