Will the original glucose transporter isoform please stand up!

A Carruthers, J DeZutter, A Ganguly… - American Journal of …, 2009 - journals.physiology.org
Monosaccharides enter cells by slow translipid bilayer diffusion by rapid, protein-mediated,
cation-dependent cotransport and by rapid, protein-mediated equilibrative transport. This …

Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis

AJ Cura, A Carruthers - Comprehensive Physiology, 2011 - Wiley Online Library
The facilitated diffusion of glucose, galactose, fructose, urate, myoinositol, and
dehydroascorbic acid in mammals is catalyzed by a family of 14 monosaccharide transport …

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

M Gynther, J Ropponen, K Laine… - Journal of medicinal …, 2009 - ACS Publications
The brain uptake of solutes is efficiently governed by the blood− brain barrier (BBB). The
BBB expresses a number of carrier-mediated transport mechanisms, and new knowledge of …

Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation

PK Khera, CH Joiner, A Carruthers, CJ Lindsell… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—To determine whether interindividual heterogeneity in the erythrocyte (red
blood cell [RBC]) transmembrane glucose gradient might explain discordances between …

Docking studies show that D-glucose and quercetin slide through the transporter GLUT1

P Cunningham, I Afzal-Ahmed, RJ Naftalin - Journal of Biological Chemistry, 2006 - ASBMB
On a three-dimensional templated model of GLUT1 (Protein Data Bank code 1SUK), a
molecular recognition program, AUTODOCK 3, reveals nine hexose-binding clusters …

Structural basis of GLUT1 inhibition by cytoplasmic ATP

DM Blodgett, JK De Zutter, KB Levine, P Karim… - The Journal of general …, 2007 - rupress.org
Cytoplasmic ATP inhibits human erythrocyte glucose transport protein (GLUT1)–mediated
glucose transport in human red blood cells by reducing net glucose transport but not …

Sugar absorption

EM Wright, M Sala-Rabanal, C Ghezzi… - Physiology of the …, 2018 - Elsevier
Carbohydrates in the diet are digested in the small intestine to glucose, galactose, and
fructose, and these sugars are then absorbed by enterocytes lining the upper third of the …

Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters

KP Lloyd, OA Ojelabi, JK De Zutter… - Journal of Biological …, 2017 - ASBMB
Recent structural studies suggest that GLUT1 (glucose transporter 1)-mediated sugar
transport is mediated by an alternating access transporter that successively presents …

Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site

JM Sage, AJ Cura, KP Lloyd… - American Journal of …, 2015 - journals.physiology.org
Glucose transporter 1 (GLUT1) is the primary glucose transport protein of the cardiovascular
system and astroglia. A recent study proposes that caffeine uncompetitive inhibition of …

Water transport by GLUT2 expressed in Xenopus laevis oocytes

T Zeuthen, E Zeuthen, N MacAulay - The Journal of physiology, 2007 - Wiley Online Library
The glucose transporter GLUT2 has been shown to also transport water. In the present
paper we investigated the relation between sugar and water transport in human GLUT2 …