On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi

BT Pfannenstiel, NP Keller - Biotechnology advances, 2019 - Elsevier
Fungi produce an abundance of bioactive secondary metabolites which can be utilized as
antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are …

Secondary metabolites from hypocrealean entomopathogenic fungi: novel bioactive compounds

L Zhang, OE Fasoyin, I Molnár, Y Xu - Natural Product Reports, 2020 - pubs.rsc.org
Covering: 2014 up to the third quarter of 2019 Entomopathogens constitute a unique,
specialized trophic subgroup of fungi, most of whose members belong to the order …

[HTML][HTML] Regulatory roles of histone modifications in filamentous fungal pathogens

Y Lai, L Wang, W Zheng, S Wang - Journal of Fungi, 2022 - mdpi.com
Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts
including plants and insects. The dynamic infection process requires rapid and fine-tuning …

Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review

K Yang, J Tian, NP Keller - Environmental Microbiology, 2022 - Wiley Online Library
Post‐translational modifications (PTMs) are important for protein function and regulate
multiple cellular processes and secondary metabolites (SMs) in fungi. Aspergillus species …

Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete?

J Collemare, MF Seidl - FEMS microbiology reviews, 2019 - academic.oup.com
Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

Comprehensive analysis of aflatoxin B1 biosynthesis in Aspergillus flavus via transcriptome-wide m6A methylome response to cycloleucine

L Liang, X Wang, H Lan, S Wei, Y Lei, S Zhang… - Journal of Hazardous …, 2024 - Elsevier
Aspergillus flavus and its toxic aflatoxins secondary metabolites contaminate food and
grains, posing a severe threat to human health and leading to liver cancer. Here, we …

[HTML][HTML] The Fusarium graminearum Histone Acetyltransferases Are Important for Morphogenesis, DON Biosynthesis, and Pathogenicity

X Kong, AD van Diepeningen… - Frontiers in …, 2018 - frontiersin.org
Post-translational modifications of chromatin structure by histone acetyltransferase (HATs)
play a central role in the regulation of gene expression and various biological processes in …

[HTML][HTML] Post-translational modifications drive success and failure of fungal–host interactions

C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

Genomic and phenotypic trait variation of the opportunistic human pathogen Aspergillus flavus and its close relatives

EA Hatmaker, M Rangel-Grimaldo, HA Raja… - Microbiology …, 2022 - Am Soc Microbiol
Fungal diseases affect millions of humans annually, yet fungal pathogens remain
understudied. The mold Aspergillus flavus can cause both aspergillosis and fungal keratitis …

Transcriptomics and metabolomic profiling identify molecular mechanism for Aspergillus flavus infection in grain

C Ding, T Tian, Q Liu, S Zhao, T Tao, H Wu… - Food Frontiers, 2023 - Wiley Online Library
Aspergillus flavus is a ubiquitous saprophyte and opportunistic fungal pathogen with
worldwide distribution, which causes diseases commonly in agricultural commodities and …