Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …

Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Researchers have applied mesenchymal stem cells (MSC) to a variety of therapeutic
scenarios by harnessing their multipotent, regenerative, and immunosuppressive properties …

Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense stroma consisting of a
prevalence of activated fibroblasts whose functional contributions to pancreatic …

Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta
(β) subunit with affinity for different extracellular membrane components. The integrin family …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Generating an unlimited source of human insulin-producing cells is a prerequisite to
advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that …

Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …

It is currently accepted that adult tissues may develop and maintain their own stem cell
pools. Because of their higher safety profile, adult stem cells may represent an ideal …

Background & Aims Although the healthy pancreas consists mostly of epithelial cells,
pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia …