In dairy cattle, late gestation is a critical period for fetal growth and physiological transition
into the next lactation. Environmental factors, such as temperature and light, exert dramatic …

Establishing sufficient skeletal muscle mass is essential for lifelong metabolic health. The
intrauterine environment is a major determinant of the muscle mass that is present for the life …

The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in
response to exposure to reduced nutrient supply. These adaptations provide survival value …

Background: Intrauterine growth restriction (IUGR) is associated with reduced β2 adrenergic
sensitivity, which contributes to poor postnatal muscle growth. The objective of this study …

Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

Intrauterine growth restriction (IUGR) arises when maternal stressors coincide with peak
placental development, leading to placental insufficiency. When the expanding nutrient …

Placental insufficiency and intrauterine growth restriction (IUGR) of the fetus affects
approximately 8% of all pregnancies and is associated with short‐and long‐term …

Fetal adaptations to placental insufficiency alter postnatal metabolic homeostasis in skeletal
muscle by reducing glucose oxidation rates, impairing insulin action, and lowering the …

Key points To investigate loss of skeletal muscle mass in intrauterine growth‐restricted
(IUGR) fetuses near term, which may result from myoblast dysfunction, we examined …

Low birth weight is an important risk factor for impaired glucose tolerance and diabetes later
in life. One hypothesis is that fetal β-cells inherit a persistent defect as a developmental …