Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …

Mitochondrial dysfunction mediated by CCCP (carbonyl cyanide m‐chlorophenyl
hydrazone), an inhibitor of mitochondrial oxidative phosphorylation, evokes the integrated …

Prior studies suggested that the transcription factor ATF4 negatively regulates synaptic
plastic and memory. By contrast, we provide evidence from direct in vitro and in vivo …

We examined the feedback between the major protein degradation pathway, the ubiquitin-
proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein …

Object recognition memory (ORM) allows identification of previously encountered items and
is therefore crucial for remembering episodic information. In rodents, reactivation during …

The translation of mRNAs is a tightly controlled process that responds to multiple signaling
pathways. In neurons, this control is also exerted locally due to the differential necessity of …

The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably
reported to either promote or inhibit neuronal plasticity and memory. However, the potential …

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta‐peptide (Aβ)
aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by …

Aims: Hippocampus is the brain center for memory formation, a process that requires
synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's …