In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

The genome organization of trypanosomes, leishmanias, and related kinetoplastid
organisms is highly unusual: Each RNA polymerase II promoter precedes multiple open …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

We report a global quantitative phosphoproteomic study of bloodstream and procyclic form
Trypanosoma brucei using SILAC labeling of each lifecycle stage. Phosphopeptide …

Control of gene expression at the post‐transcriptional level is essential in all organisms, and
RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand …

In trypanosomatids, gene expression is regulated mainly by post-transcriptional
mechanisms, which affect mRNA processing, translation and degradation. Currently, our …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

One of the key questions in understanding the biology of an organism is how to correlate
cellular fate and function with gene expression patterns. This is particularly relevant for …

In most organisms, the heat-shock response involves increased heat-shock gene
transcription. In Kinetoplastid protists, however, virtually all control of gene expression is …

African trypanosomes are sustained in the bloodstream of their mammalian hosts by their
extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes …