Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of developing lung cancer is six times greater in individuals with COPD …

Rationale: Proteolysis is a key aspect of the lung's innate immune system. Proteases,
including neutrophil elastase and MMPs (matrix metalloproteases), modulate cell signaling …

Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …

Simple Summary Multifactorial diseases are caused by a combination of genetic and
environmental factors and various risk factors that accumulate with age. Cardiovascular …

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …

Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of
morbidity and mortality worldwide, characterized by persistent respiratory symptoms and …

In recent years, RNA-based therapies have gained much attention as biomedicines due to
their remarkable therapeutic effects with high specificity and potency. Lung diseases offer a …

Introduction Although different phenotypes of lung disease after preterm birth have recently
been described, the underlying mechanisms associated with each phenotype are poorly …

Background Electronic cigarette (e-cigarette) vapour is gaining popularity as an alternative
to tobacco smoking and can induce acute lung injury. However, the specific role of nicotine …