Clinical and translational attributes of immune-related adverse events
KPM Suijkerbuijk, MJM van Eijs, F van Wijk… - Nature Cancer, 2024 - nature.com
With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many
cancers, managing their immune-related adverse events (irAEs) has become an important …
cancers, managing their immune-related adverse events (irAEs) has become an important …
[HTML][HTML] Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial
YL Verschoor, J van de Haar, JG van den Berg… - Nature medicine, 2024 - nature.com
Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite
recent advancements, most patients die of their disease. Although immune checkpoint …
recent advancements, most patients die of their disease. Although immune checkpoint …
[HTML][HTML] From Reductionistic Approach to Systems Immunology Approach for the Understanding of Tumor Microenvironment
N Koelsch, MH Manjili - International Journal of Molecular Sciences, 2023 - mdpi.com
The tumor microenvironment (TME) is a complex and dynamic ecosystem that includes a
variety of immune cells mutually interacting with tumor cells, structural/stromal cells, and …
variety of immune cells mutually interacting with tumor cells, structural/stromal cells, and …
Interruption of the intratumor CD8+ T cell: Treg crosstalk improves the efficacy of PD-1 immunotherapy
SN Geels, A Moshensky, RS Sousa, C Murat… - Cancer Cell, 2024 - cell.com
PD-1 blockade unleashes potent antitumor activity in CD8+ T cells but can also promote
immunosuppressive T regulatory (Treg) cells, which may worsen the response to …
immunosuppressive T regulatory (Treg) cells, which may worsen the response to …
[HTML][HTML] Recent research and clinical progress of CTLA-4-based immunotherapy for breast cancer
H Zhang, J Mi, Q Xin, W Cao, C Song, N Zhang… - Frontiers in …, 2023 - frontiersin.org
Breast cancer is characterized by a high incidence rate and its treatment challenges,
particularly in certain subtypes. Consequently, there is an urgent need for the development …
particularly in certain subtypes. Consequently, there is an urgent need for the development …
[HTML][HTML] Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in …
R Salembier, C De Haes, J Bellemans… - Breast Cancer …, 2024 - Springer
Abstract Background Chitinase-like proteins (CLPs) play a key role in immunosuppression
under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become …
under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become …
Interruption of the Intratumor CD8: Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy
SUMMARY PD-1 blockade unleashes the potent antitumor activity of CD8 cells but can also
promote immunosuppressive T regulatory (Treg) cells, which may worsen response to …
promote immunosuppressive T regulatory (Treg) cells, which may worsen response to …