Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

The spinal cord is a fascinating structure that is responsible for coordinating movement in
vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which a
greater understanding of early disease mechanisms is needed to reveal novel therapeutic …

In vertebrates, motor control relies on cholinergic neurons in the spinal cord that have been
extensively studied over the past hundred years, yet the full heterogeneity of these neurons …

Mammalian motor programs are controlled by networks of spinal interneurons that set the
rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive …

Delaying clinical disease onset would greatly reduce neurodegenerative disease burden,
but the mechanisms influencing early preclinical progression are poorly understood. Here …

Spinal interneurons are organized into networks that control the activity and output of the
motor system. This review outlines recent progress in defining the rules that govern the …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory
modalities including the sense of light touch. Here, we identify a population of excitatory …