Neuroprotection in stroke: past, present, and future

A Majid - International Scholarly Research Notices, 2014 - Wiley Online Library
Stroke is a devastating medical condition, killing millions of people each year and causing
serious injury to many more. Despite advances in treatment, there is still little that can be …

Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction

B Forreider, D Pozivilko, Q Kawaji, X Geng… - Progress in …, 2017 - Elsevier
Many mammalian species naturally undergo hibernation, a process that is associated with
drastic changes in metabolism and systemic physiology. Their ability to retain an …

Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke

M Dai, B Chen, X Wang, C Gao, H Yu - Metabolic Brain Disease, 2021 - Springer
Therapeutic hypothermia (TH) is a promising neuroprotective agent for treating stroke.
However, its clinical application was limited by the impractical duration. Icariin (ICA) were …

Enhanced apoptosis from early physical exercise rehabilitation following ischemic stroke

F Li, W Shi, EY Zhao, X Geng, X Li… - Journal of …, 2017 - Wiley Online Library
The effectiveness of the rehabilitative benefits of physical exercise appears to be contingent
upon when the exercise is initiated after stroke. The present study assessed the hypothesis …

Exacerbation of brain injury by post-stroke exercise is contingent upon exercise initiation timing

F Li, X Geng, H Khan, JT Pendy Jr, C Peng… - Frontiers in cellular …, 2017 - frontiersin.org
Accumulating evidence has demonstrated that post-stroke physical rehabilitation may
reduce morbidity. The effectiveness of post-stroke exercise, however, appears to be …

Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat

D Wu, J Shi, O Elmadhoun, Y Duan, H An, J Zhang… - Brain Research, 2017 - Elsevier
Objective Hypothermia has demonstrated neuroprotection following ischemia in preclinical
studies while its clinical application is still very limited. The aim of this study was to explore …

Chronic consumption of alcohol increases alveolar bone loss

JM de Almeida, VFC Pazmino, VCN Novaes… - PLoS …, 2020 - journals.plos.org
This study evaluated the effects of the chronic consumption of different concentrations of
alcohol on the experimental periodontitis (EP). 160 rats were divided into 4 groups:(EP-NT) …

Combining normobaric oxygen with ethanol or hypothermia prevents brain damage from thromboembolic stroke via PKC-Akt-NOX modulation

L Cai, J Stevenson, X Geng, C Peng, X Ji, R Xin… - Molecular …, 2017 - Springer
In a thromboembolic stroke model after reperfusion by recombinant tissue plasminogen
activator (rt-PA), we aimed to determine whether therapeutic hypothermia (TH) and ethanol …

Shengmai injection attenuates the cerebral ischemia/reperfusion induced autophagy via modulation of the AMPK, mTOR and JNK pathways

H Yang, L Li, K Zhou, Y Wang, T Guan… - Pharmaceutical …, 2016 - Taylor & Francis
Context Shengmai injection (SMI) is a patented Chinese medicine originated from the
ancient Chinese herbal compound Shengmai san, which is used extensively for the …

Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX)

J Shen, M Huber, EY Zhao, C Peng, F Li, X Li, X Geng… - Brain research, 2016 - Elsevier
Introduction Although physical exercise has emerged as a potential therapeutic modality for
functional deficits following ischemic stroke, the extent of this effect appears to be contingent …