The global malaria burden sometimes obscures that the genus Plasmodium comprises
diverse clades with lineages that independently gave origin to the extant human parasites …

Intracellular protozoan parasites have evolved an efficient protein quality control (PQC)
network comprising protein folding and degradation machineries that protect the parasite's …

The decay constant k in the antecedent precipitation index (API) formula is generally
determined arbitrarily and empirically, which causes great confusion in API calculation and …

Background Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the
disease malaria in low-transmission regions outside of Africa. These regions often feature …

The human malaria parasite Plasmodium falciparum genome is among the most A+ T rich,
with low complexity regions (LCRs) inserted in coding sequences including those for …

Volatile low complexity regions (LCRs) are a novel source of adaptive variation, functional
diversification and evolutionary novelty. An interplay of selection and mutation governs the …

Malaria is a life-threatening and devastating parasitic disease. Our previous work showed
that parasite development requires the import of exogenous transfer RNAs (tRNAs), which …

Abstract tRNAs are not only essential for decoding the genetic code, but their abundance
also has a strong impact on the rate of protein production, folding, and on the stability of the …

Aminoacyl-tRNA synthetases (aaRSs) attach amino acids to their cognate transfer RNAs. In
eukaryotes, a subset of cytosolic aaRSs is organized into a multisynthetase complex (MSC) …

Low complexity regions (LCRs) differ in amino acid composition from the background
provided by the corresponding proteomes. The simplest LCRs are homorepeats (or polyX) …