Patients with leukemia who receive a T cell–depleted allogeneic stem cell graft followed by
postponed donor lymphocyte infusion (DLI) can experience graft-versus-leukemia (GVL) …

Since multiple different T-cell receptor (TCR) sequences can bind to the same peptide-MHC
combination and the number of TCR-sequences that can theoretically be generated even …

B cells recognize specific antigens by their membrane-bound B-cell receptor (BCR).
Functional BCR genes are assembled in pre-B cells by recombination of the variable (V) …

In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-
DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T …

Background Adoptive transfer of genetically engineered T cells expressing antigen-specific
T-cell receptors (TCRs) is an appealing therapeutic approach for Epstein-Barr virus (EBV) …

Adoptive cellular therapies with T cells are increasingly used to treat a variety of conditions.
For instance, in a recent phase 1/2 trial, we prophylactically administered multivirus-specific …

Tumor-associated antigens (TAAs) are monomorphic self-antigens that are proposed as
targets for immunotherapeutic approaches to treat malignancies. We investigated whether T …

IgE-mediated allergic disease represents an increasing health problem. Although numerous
studies have investigated IgE sequences in allergic patients, little information is available on …

Anti‐viral T‐cell responses are usually directed against a limited set of antigens, but often
contain many T cells expressing different T‐cell receptors (TCRs). Identical TCRs found …

The expression of a functional antigen receptor is necessary for cell survival of normal B
lymphocytes and most B-cell neoplasms alike. When the genetic modifications of the B-cell …