Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

B Dubois, N Villain, GB Frisoni, GD Rabinovici… - The Lancet …, 2021 - thelancet.com
Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life

KA Walker, J Chen, L Shi, Y Yang, M Fornage… - Science translational …, 2023 - science.org
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …

Machine learning and eye movements give insights into neurodegenerative disease mechanisms

AW Przybyszewski, A Śledzianowski, A Chudzik… - Sensors, 2023 - mdpi.com
Humans are a vision-dominated species; what we perceive depends on where we look.
Therefore, eye movements (EMs) are essential to our interactions with the environment, and …

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience

A Kumar, SS Karuppagounder, Y Chen, C Corona… - Neuron, 2023 - cell.com
Intermittent fasting (IF) is a diet with salutary effects on cognitive aging, Alzheimer's disease
(AD), and stroke. IF restricts a number of nutrient components, including glucose. 2 …

Prediction of Alzheimer's disease progression with multi-information generative adversarial network

Y Zhao, B Ma, P Jiang, D Zeng… - IEEE Journal of …, 2020 - ieeexplore.ieee.org
Alzheimer's disease (AD) is a chronic neurodegenerative disease, and its long-term
progression prediction is definitely important. The structural Magnetic Resonance Imaging …

Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease

SS Lavekar, J Harkin, M Hernandez, C Gomes… - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …

Apathy and APOE in mild behavioral impairment, and risk for incident dementia

D Vellone, M Ghahremani, Z Goodarzi… - … Research & Clinical …, 2022 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is a high‐risk state for incident dementia and
comprises five core domains including affective dysregulation, impulse dyscontrol, social …

Longitudinal atrophy in early Braak regions in preclinical Alzheimer's disease

L Xie, LEM Wisse, SR Das, N Vergnet… - Human brain …, 2020 - Wiley Online Library
A major focus of Alzheimer's disease (AD) research has been finding sensitive outcome
measures to disease progression in preclinical AD, as intervention studies begin to target …

[HTML][HTML] Real-time, personalized medicine through wearable sensors and dynamic predictive modeling: a new paradigm for clinical medicine

J Tyler, SW Choi, M Tewari - Current opinion in systems biology, 2020 - Elsevier
Accurately predicting the onset and course of a disease in an individual is a major unmet
challenge in medicine due to the complex and dynamic nature of disease progression …

Automatic Analysis of MRI Images for Early Prediction of Alzheimer's Disease Stages Based on Hybrid Features of CNN and Handcrafted Features

A Khalid, EM Senan, K Al-Wagih, MM Ali Al-Azzam… - Diagnostics, 2023 - mdpi.com
Alzheimer's disease (AD) is considered one of the challenges facing health care in the
modern century; until now, there has been no effective treatment to cure it, but there are …