Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

Abstract Sestrin2 (SESN2), a highly conserved stress-responsive protein, can be triggered
by various noxious stimuli, such as hypoxia, DNA damage, oxidative stress, endoplasmic …

Traumatic brain injury (TBI), as a serious central nervous system disease, can result in
severe neurological dysfunction or even disability and death of patients. The early and …

As a dominant mycotoxin, zearalenone (ZEA) has attracted extensive attention due to its
estrogen‐like effect and oxidative stress damage in cells. In order to find a way to relieve cell …

A timely and adequate response to stress is inherently present in each cell and is important
for maintaining the proper functioning of the cell in changing intracellular and extracellular …

Increased expression of secreted frizzled related protein 3 (SFRP3) is associated with
adverse outcomes of heart failure. The purpose of this study was to investigate the effect of …

Leucine is the native known ligand of Sestrin2 (Sesn2) and its interaction with Sesn2 is
particularly important, as it influences the activity of mTOR in aging and its associated …

Diabetes is a global health problem which is accompanied with multi-systemic
complications. It is of great significance to elucidate the pathogenesis and to identify novel …

Objective PCOS (polycystic ovary syndrome) is one of the most common endocrinological
disorders and it is the threshold of many systemic disorders. There are many studies in the …

Objectives: Endothelial-to-mesenchymal transition (EndoMT) is a significant biological
phenomenon wherein endothelial cells undergo a loss of their endothelial traits and …