Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

The neocortex of the human brain is the seat of higher brain function. Modern imaging
techniques, chief among them magnetic resonance imaging (MRI), allow non-invasive …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Neurite orientation dispersion and density imaging (NODDI) has become a popular diffusion
MRI technique for investigating microstructural alternations during brain development …

The conduction velocity (CV) of action potentials along axons is a key neurophysiological
property central to neural communication. The ability to estimate CV in humans in vivo from …

Background The g-ratio, quantifying the comparative thickness of the myelin sheath
encasing an axon, is a geometrical invariant that has high functional relevance because of …

Myelin defects cause a collection of myelin disorders in the brain. The lack of human models
has limited us from better understanding pathological mechanisms of myelin diseases …

Recent research has highlighted the role of complement genes in shaping the
microstructure of the brain during early development, and in contributing to common allele …

Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …