Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional
changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Lysine acetylation has emerged as a major posttranslational modification for histones.
Crossregulation between this and other modifications is crucial in modulating chromatin …

Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression
as well as the functions of more than 50 transcription factors and nonhistone proteins. We …

Background: MicroRNA-22 (miR-22) has recently been reported to play a regulatory role
during vascular smooth muscle cell (VSMC) differentiation from stem cells, but little is known …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …