Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …

Abstract Quinazoline‐2, 4 (1H, 3H)‐dione is a significant class of N‐fused heterocyclic with a
wide range of biological functions, including anti‐HIV, anticancer, antifungal, antibacterial …

Novel antimalarial therapeutics that target multiple stages of the parasite lifecycle are
urgently required to tackle the emerging problem of resistance with current drugs. Here, we …

A series of novel quinazolines as tubulin inhibitors occupying three zones of colchicine
domain have been designed and synthesized inspired by the recently disclosed crystal …

We disclose a method using phenyl isocyanate to synthesize carbonyl-containing N-
heterocycles. The metal-free novel approach for both N–H and C–H carbonylation …

An N-heterocyclic carbene (NHC) catalyzed enantio-and diastereoselective [12+ 2]
cycloaddition is disclosed to rapidly construct sophisticated molecules bearing a tricyclic …

Abstract Quinazoline-2, 4 (1H, 3H)-dione is a major class of N-fused heterocyclic with a wide
range of biological functions, including anti-HIV, anticancer, antifungal, antibacterial …

A facile DABCO promoted one-pot three component synthesis of a new series of C–C linked
bis-heterocycle containing dihydropyrano [c] chromene as highly fused oxa-heteryl group at …

As a G-protein coupled receptor, the 5-hydroxytryptamine 2A (5-HT2A) receptor is known for
its critical role in the cognitive, behavioural and physiological functions, and thus is a primary …

The 4-aminoquinazoline scaffold is a privileged structure in medicinal chemistry.
Regioselective nucleophilic aromatic substitution (SNAr) for replacing the chlorine atom at …