Hypoxia and HIF signaling: one axis with divergent effects

C Corrado, S Fontana - International Journal of Molecular Sciences, 2020 - mdpi.com
The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

Liver regeneration after hepatectomy and partial liver transplantation

S Yagi, M Hirata, Y Miyachi, S Uemoto - International Journal of …, 2020 - mdpi.com
The liver is a unique organ with an abundant regenerative capacity. Therefore, partial
hepatectomy (PHx) or partial liver transplantation (PLTx) can be safely performed. Liver …

Operative results and oncologic outcomes of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus two-stage hepatectomy (TSH) …

D Moris, S Ronnekleiv-Kelly, ID Kostakis… - World journal of …, 2018 - Springer
Background Associating liver partition and portal vein ligation for staged hepatectomy
(ALPPS) has recently emerged as a treatment choice for patients with colorectal liver …

Influence of cytokines, circulating markers and growth factors on liver regeneration and post-hepatectomy liver failure: a systematic review and meta-analysis

A Murtha-Lemekhova, J Fuchs, O Ghamarnejad… - Scientific reports, 2021 - nature.com
The pathophysiology of post-hepatectomy liver failure is not entirely understood but is rooted
in the disruption of normal hepatocyte regeneration and homeostasis. Current investigations …

Simultaneous portal and hepatic vein embolization before major liver resection

J Heil, E Schadde - Langenbeck's archives of surgery, 2021 - Springer
Background Regenerative liver surgery expands the limitations of technical resectability by
increasing the future liver remnant (FLR) volume before extended resections in order to …

Hypoxia-inducible factors as key players in the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

LMW Holzner, AJ Murray - Frontiers in medicine, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) and its more severe form non-alcoholic
steatohepatitis (NASH) are a major public health concern with high and increasing global …

Preoperative portal vein embolization alone with biliary drainage compared to a combination of simultaneous portal vein, right hepatic vein embolization and biliary …

A Hocquelet, C Sotiriadis, R Duran, B Guiu… - Cardiovascular and …, 2018 - Springer
Purpose To compare estimated future remnant liver (FRL) growth following portal vein
embolization or liver venous deprivation (LVD)(combined PVE and right hepatic vein …

The HPB controversy of the decade: 2007–2017–Ten years of ALPPS

PB Olthof, AA Schnitzbauer, E Schadde - European Journal of Surgical …, 2018 - Elsevier
Ten years ago the first patient underwent Associating Liver Partition and Portal Vein Ligation
for Staged Hepatectomy (ALPPS). This report aimed to critically review literature on ALPPS …

[HTML][HTML] Liver hypertrophy: underlying mechanisms and promoting procedures before major hepatectomy

B Le Roy, A Dupré, A Gallon, P Chabrot… - Journal of visceral …, 2018 - Elsevier
Various procedures can promote hypertrophy of the future liver remnant (FLR) before major
hepatectomy to prevent postoperative liver failure. The pathophysiological situation …

Simultaneous hepatic and portal vein ligation induces rapid liver hypertrophy: a study in pigs

E Schadde, B Guiu, R Deal, J Kalil, B Arslan, J Tasse… - Surgery, 2019 - Elsevier
Background Liver hypertrophy induced by partial portal vein occlusion (PVL) is accelerated
by adding simultaneous parenchymal transection (“ALPPS procedure”). This preclinical …