Cystatins have recently emerged as important players in a multitude of physiological and
patho-physiological settings that range from cell survival and proliferation, to differentiation …

Metallocarboxpeptidases cleave C-terminal residues from peptide substrates and participate
in a wide range of physiological processes, but they also contribute to human pathology. On …

Malignant melanoma is a common and frequently lethal disease. Current therapeutic
interventions have little effect on survival, emphasizing the need for a better understanding …

We describe a positional proteomics approach to simultaneously analyze N-and C-terminal
peptides and used it to screen for human protein substrates of granzyme B and …

Metallocarboxypeptidases (MCPs) are commonly regarded as exopeptidases that actively
participate in the digestion of proteins and peptides. In the recent years, however, novel …

When mast cells are activated they can respond by releasing their secretory granule
compounds, including mast cell-specific proteases of chymase, tryptase and …

Cryo-electron microscopy (cryo-EM) has become a mainstream technique for determining
the structures of complex biological systems. However, accurate integrative structural …

Electron cryotomography enables 3D visualization of cells in a near-native state at
molecular resolution. The produced cellular tomograms contain detailed information about a …

Meprin α and β, zinc metalloproteinases, play significant roles in inflammation, including
inflammatory bowel disease (IBD), possibly by activating cytokines, like interleukin 1β …

The mouse haematopoietic stem cell (SC) regulator Latexin (LXN) is the only known
homologue of the retinoic acid receptor responder 1 (RARRES1) gene. Both genes lie …