Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

Heart regeneration, a relatively new field of biology, is one of the most active and
controversial areas of biomedical research. The potential impact of successful human heart …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Background: Adult mammalian hearts have a limited ability to generate new cardiomyocytes.
Proliferation of existing adult cardiomyocytes (ACMs) is a potential source of new …

Human pluripotent stem cell-derived cardiomyocytes (CMs) are a promising tool for cardiac
cell therapy. Although transplantation of induced pluripotent stem cell (iPSC)-derived CMs …