Multiple hydrogen bonding driven supramolecular architectures and their biomedical applications
Y Liu, L Wang, L Zhao, Y Zhang, ZT Li… - Chemical Society …, 2024 - pubs.rsc.org
Supramolecular chemistry combines the strength of molecular assembly via various
molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of …
molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of …
Secondary structures of synthetic polypeptide polymers
C Bonduelle - Polymer Chemistry, 2018 - pubs.rsc.org
Synthetic peptide-based polymers represent a unique class of macromolecules able to
mimic the properties of natural proteins in materials sciences since (1) they present the …
mimic the properties of natural proteins in materials sciences since (1) they present the …
Myotonic dystrophies: state of the art of new therapeutic developments for the CNS
Myotonic dystrophies are multisystemic diseases characterized not only by muscle and heart
dysfunction but also by CNS alteration. They are now recognized as brain diseases affecting …
dysfunction but also by CNS alteration. They are now recognized as brain diseases affecting …
An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action
Z Chen, C Zhou, Y Xu, K Wen, J Song, S Bai, C Wu… - Biomaterials, 2021 - Elsevier
The increasing number of infections caused by multi-drug resistance (MDR) bacteria is an
omen of a new global challenge. As one of the countermeasures under development …
omen of a new global challenge. As one of the countermeasures under development …
Helix-specific properties and applications in synthetic polypeptides
Polypeptides obtained from the ring-opening polymerization of N-carboxyanhydrides, as the
synthetic analogues of natural proteins, have drawn broad interests during the recent three …
synthetic analogues of natural proteins, have drawn broad interests during the recent three …
Multivalent engineering of exosomes with activatable aptamer probes for specific regulation and monitoring of cell targeting
W Liu, Y Huang, Z Li, L Li, Y Zhao, M Li - Analytical Chemistry, 2022 - ACS Publications
Reconstituting and probing exosome-cell interactions is critical for elucidating exosome-
related cell biology and advancing their diagnostic and therapeutic potential. We report here …
related cell biology and advancing their diagnostic and therapeutic potential. We report here …
Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
Developing highly active, multivalent ligands as therapeutic agents is challenging because
of delivery issues, limited cell permeability, and toxicity. Here, we report intrinsically cell …
of delivery issues, limited cell permeability, and toxicity. Here, we report intrinsically cell …
Brain pathogenesis and potential therapeutic strategies in myotonic dystrophy type 1
J Liu, ZN Guo, XL Yan, Y Yang… - Frontiers in aging …, 2021 - frontiersin.org
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy that affects
multiple systems including the muscle and heart. The mutant CTG expansion at the 3′-UTR …
multiple systems including the muscle and heart. The mutant CTG expansion at the 3′-UTR …
Bioinspired multivalent peptide nanotubes for sialic acid targeting and imaging‐guided treatment of metastatic melanoma
L Lei, Z Xu, X Hu, Y Lai, J Xu, B Hou, Y Wang, H Yu… - Small, 2019 - Wiley Online Library
Tumor metastasis is considered a major cause of cancer‐related human mortalities.
However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent …
However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent …
Different-length hydrazone activated polymers for plasmid DNA condensation and cellular transfection
JM Priegue, I Lostalé-Seijo, D Crisan… - …, 2018 - ACS Publications
The recent advances in genetic engineering demand the development of conceptually new
methods to prepare and identify efficient vectors for the intracellular delivery of different …
methods to prepare and identify efficient vectors for the intracellular delivery of different …