Multiple hydrogen bonding driven supramolecular architectures and their biomedical applications

Y Liu, L Wang, L Zhao, Y Zhang, ZT Li… - Chemical Society …, 2024 - pubs.rsc.org
Supramolecular chemistry combines the strength of molecular assembly via various
molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of …

Secondary structures of synthetic polypeptide polymers

C Bonduelle - Polymer Chemistry, 2018 - pubs.rsc.org
Synthetic peptide-based polymers represent a unique class of macromolecules able to
mimic the properties of natural proteins in materials sciences since (1) they present the …

Myotonic dystrophies: state of the art of new therapeutic developments for the CNS

G Gourdon, G Meola - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Myotonic dystrophies are multisystemic diseases characterized not only by muscle and heart
dysfunction but also by CNS alteration. They are now recognized as brain diseases affecting …

An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action

Z Chen, C Zhou, Y Xu, K Wen, J Song, S Bai, C Wu… - Biomaterials, 2021 - Elsevier
The increasing number of infections caused by multi-drug resistance (MDR) bacteria is an
omen of a new global challenge. As one of the countermeasures under development …

Helix-specific properties and applications in synthetic polypeptides

N Li, Y Lei, Z Song, L Yin - Current Opinion in Solid State and Materials …, 2023 - Elsevier
Polypeptides obtained from the ring-opening polymerization of N-carboxyanhydrides, as the
synthetic analogues of natural proteins, have drawn broad interests during the recent three …

Multivalent engineering of exosomes with activatable aptamer probes for specific regulation and monitoring of cell targeting

W Liu, Y Huang, Z Li, L Li, Y Zhao, M Li - Analytical Chemistry, 2022 - ACS Publications
Reconstituting and probing exosome-cell interactions is critical for elucidating exosome-
related cell biology and advancing their diagnostic and therapeutic potential. We report here …

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

JY Lee, Y Bai, UV Chembazhi, S Peng… - Proceedings of the …, 2019 - National Acad Sciences
Developing highly active, multivalent ligands as therapeutic agents is challenging because
of delivery issues, limited cell permeability, and toxicity. Here, we report intrinsically cell …

Brain pathogenesis and potential therapeutic strategies in myotonic dystrophy type 1

J Liu, ZN Guo, XL Yan, Y Yang… - Frontiers in aging …, 2021 - frontiersin.org
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy that affects
multiple systems including the muscle and heart. The mutant CTG expansion at the 3′-UTR …

Bioinspired multivalent peptide nanotubes for sialic acid targeting and imaging‐guided treatment of metastatic melanoma

L Lei, Z Xu, X Hu, Y Lai, J Xu, B Hou, Y Wang, H Yu… - Small, 2019 - Wiley Online Library
Tumor metastasis is considered a major cause of cancer‐related human mortalities.
However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent …

Different-length hydrazone activated polymers for plasmid DNA condensation and cellular transfection

JM Priegue, I Lostalé-Seijo, D Crisan… - …, 2018 - ACS Publications
The recent advances in genetic engineering demand the development of conceptually new
methods to prepare and identify efficient vectors for the intracellular delivery of different …