The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Two major initiatives are under way to correct the β-cell deficit of diabetes: one would
generate β-cells ex vivo that are suitable for transplantation, and the second would stimulate …

Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers
including endodermal cells that produce insulin in vitro. We show that constitutive …

The study of how human embryonic stem cells (hESCs) differentiate into insulin-producing
beta cells has twofold significance: first, it provides an in vitro model system for the study of …

Aims/hypothesis The relative lack of successful pancreatic differentiation of human
embryonic stem cells (hESCs) may suggest that directed differentiation of hESCs into …

Several recent reports claim the generation of insulin-producing cells from embryonic stem
cells via the differentiation of progenitors that express nestin. Here, we investigate further the …

Disclosed herein are cell cultures comprising de? nitive endo derm cells and methods of
producing the same. Also dis closed herein are cell populations comprising substantially …

The differentiated state of mature cells of adult organisms is achieved and maintained
through the epigenetic regulation of gene expression, which consists of several mechanisms …

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

Context Curative therapy for diabetes mellitus mainly implies replacement of functional
insulin-producing pancreatic β cells, with pancreas or islet-cell transplants. However …