The purpose of this article is to describe dependence and withdrawal phenomena related to
CNS drugs discontinuation and to clarify issues related to the evaluation of clinical drug …

Pharmacologic interventions are commonly used to support rehabilitation efforts of patients
with disorders of consciousness (DoC). The 2018 practice guidelines recommend …

Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the
α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option …

Background Z-drugs are hypnotic drugs used for insomnia with considerable potential of
abuse. We investigated the relationship of past-year medical and non-medical use of z …

Objective To investigate whether zolpidem use is associated with suicide death in adults.
Method We conducted a case–control study using the National Health Insurance Service …

Zolpidem is a non-benzodiazepine agent used for short-term treatment of insomnia. Several
cases of dependence and withdrawal from zolpidem are reported in the literature …

The human population has been witnessing an increase in the number of diseases which
are a consequence of progressively increasing physical and mental stress. Insomnia is one …

Purpose To determine changes in the prevalence of zolpidem consumption since the
change in the regulations of prescription. Formulations containing zolpidem were subject to …

Background Insomnia is a major health issue, and zolpidem is an effective treatment for
insomnia. However, high doses of zolpidem can cause dependence, abuse, and withdrawal …

Although believed safer compared to short-acting benzodiazepines (BZD), in the past few
years a growing concern has developed relating to the abuse of Z-drugs, and specifically of …