Severe obesity affects the health and well-being of millions of children and adolescents in
the United States and is widely considered to be an “epidemic within an epidemic” that …

A growing number of youth suffer from obesity and in particular severe obesity for which
intensive lifestyle intervention does not adequately reduce excess adiposity. A treatment gap …

Background The prevalence of severe obesity among children and young adults has
increased over the past decade. Although the prevalence of cardiometabolic risk factors is …

Severe obesity afflicts between 4% and 6% of all youth in the United States, and the
prevalence is increasing. Despite the serious immediate and long-term cardiovascular …

Pediatric obesity is a highly prevalent chronic disease, which has traditionally been treated
with lifestyle therapy alone. Yet for many youth, lifestyle intervention as a monotherapy is …

This study aimed to develop a multidisciplinary lifestyle intervention program targeted at
children and adolescents with moderate to severe obesity, and assess the additional effects …

Importance Medical treatment options for pediatric obesity remain limited. Glucagon-like
peptide-1 (GLP-1) receptor agonists induce weight loss by suppressing appetite and …

Objective Morbid obesity is the fastest growing subcategory of childhood obesity, associated
with an increased health risk that persists into adulthood. There is an urgent need to develop …

The objective of this pilot study was to evaluate the effects of exenatide on BMI (primary
endpoint) and cardiometabolic risk factors in nondiabetic youth with extreme obesity. Twelve …

Importance Severe childhood obesity has become a major health problem, and effective,
evidence-based interventions are needed. The relative effectiveness of inpatient compared …