A meta‐analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis
MM van de Meeberg, RCF Hebing… - British journal of …, 2023 - Wiley Online Library
Aims In immune‐mediated inflammatory diseases (IMIDs), early symptom control is a key
therapeutic goal. Methotrexate (MTX) is the first‐line treatment across IMIDs. However, MTX …
therapeutic goal. Methotrexate (MTX) is the first‐line treatment across IMIDs. However, MTX …
[HTML][HTML] Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Methotrexate (MTX) is a folate antagonist drug used for several diseases, such as cancers,
various malignancies, rheumatoid arthritis (RA) and inflammatory bowel disease. Due to its …
various malignancies, rheumatoid arthritis (RA) and inflammatory bowel disease. Due to its …
DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a …
SN Nielsen, K Grell, J Nersting, J Abrahamsson… - The Lancet …, 2017 - thelancet.com
Background Adjustment of mercaptopurine and methotrexate maintenance therapy of acute
lymphoblastic leukaemia by leucocyte count is confounded by natural variations. Cytotoxicity …
lymphoblastic leukaemia by leucocyte count is confounded by natural variations. Cytotoxicity …
Capillary blood collected on volumetric absorptive microsampling (VAMS) device for monitoring hydroxychloroquine in rheumatoid arthritis patients
Y Qu, K Brady, R Apilado, T O'Malley, S Reddy… - … of Pharmaceutical and …, 2017 - Elsevier
A novel technique for collection of capillary blood, termed volumetric absorptive
microsampling (VAMS), has been recently cleared by the FDA for collection of human blood …
microsampling (VAMS), has been recently cleared by the FDA for collection of human blood …
Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in patients with rheumatoid arthritis
MCFJ De Rotte, E Den Boer, PHP De Jong… - Annals of the …, 2015 - ard.bmj.com
Objective To investigate if erythrocyte-methotrexate-polyglutamate (MTX-PG) concentrations
in patients with rheumatoid arthritis (RA) are associated with disease activity or adverse …
in patients with rheumatoid arthritis (RA) are associated with disease activity or adverse …
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease
MM van de Meeberg, HH Fidder… - Alimentary …, 2023 - Wiley Online Library
Background Therapeutic drug monitoring (TDM) has the potential to improve efficacy and
diminish side effects. Measuring methotrexate‐polyglutamate (MTX‐PG) in erythrocytes …
diminish side effects. Measuring methotrexate‐polyglutamate (MTX‐PG) in erythrocytes …
[HTML][HTML] Treatment of rheumatoid arthritis using combination of methotrexate and tripterygium glycosides tablets—a quantitative plasma pharmacochemical and …
M Wang, J Huang, H Fan, D He, S Zhao… - Frontiers in …, 2018 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic
destructive synovitis and is associated with progressive disability, systemic difficulties …
destructive synovitis and is associated with progressive disability, systemic difficulties …
[HTML][HTML] Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis
T Yamamoto, K Shikano, T Nanki, S Kawai - Scientific reports, 2016 - nature.com
We investigated major determinants of the intracellular concentrations of methotrexate
polyglutamates (MTXPGs) in patients with rheumatoid arthritis (RA). In 271 RA patients on …
polyglutamates (MTXPGs) in patients with rheumatoid arthritis (RA). In 271 RA patients on …
[HTML][HTML] Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia
E Driehuis, N Oosterom, SG Heil, IB Muller, M Lin… - PLoS …, 2020 - journals.plos.org
We have recently established a protocol to grow wildtype human oral mucosa organoids.
These three-dimensional structures can be maintained in culture long-term, do not require …
These three-dimensional structures can be maintained in culture long-term, do not require …
[HTML][HTML] Quantitation of methotrexate polyglutamates in human whole blood, erythrocytes and leukocytes collected via venepuncture and volumetric absorptive micro …
DN Daraghmeh, M Moghaddami… - Analytical and …, 2022 - Springer
Low-dose methotrexate (MTX) plays a key role in treatment of rheumatoid arthritis. However,
not all patients respond satisfactorily, and no therapeutic drug monitoring has been …
not all patients respond satisfactorily, and no therapeutic drug monitoring has been …