Major depression shortens life while the effectiveness of frontline treatments remains
modest. Exercise has been shown to be effective both in reducing mortality and in treating …

The present study pooled the prevalence of sleep disturbances and depression in
community-dwelling older adults (mean age≥ 60 years) and quantified the strength of …

Background Elderly patients with major depression have a poorer prognosis, are less
responsive to treatment, and show greater functional decline compared with younger …

Mental health disorders often arise as a combination of environmental and genetic factors.
The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key …

One of the most consistent findings in the biology of depression is an altered activity of the
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …

Depression has been shown to negatively impact neurocognitive functions, particularly
those governed by fronto-subcortical networks, such as executive functions. Converging …

Background Vascular depression is regarded as a subtype of late-life depression
characterized by a distinct clinical presentation and an association with cerebrovascular …

Resting-state fMRI studies investigating the pathophysiology of depression have identified
prominent abnormalities in large-scale brain networks. However, it is unclear if localized …

Depression in elderlies is not known quite well and thus cannot be treated adequately. The
fact that elderliness is accepted as a property of depressive symptoms both by the relatives …

Late-life depression is frequently associated with cognitive impairment. Depressive
symptoms are often associated with or even precede a dementia syndrome. Moreover …