Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Background Nitrogen sources play an essential role in maintaining the physiological and
biochemical activity of bacteria. Nitrogen metabolism, which is the core of microorganism …

One of the most salient features of life is its capacity to handle novelty and namely to thrive
and adapt to new circumstances and changes in both the environment and internal …

Genome-scale metabolic networks (GSMs) are fundamental systems biology
representations of a cell's entire set of stoichiometrically balanced reactions. However, such …

Much recent progress has been made to understand the impact of proteome allocation on
bacterial growth; much less is known about the relationship between the abundances of the …

Microbial systems biology has made enormous advances in relating microbial physiology to
the underlying biochemistry and molecular biology. By meticulously studying model …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Genome-scale metabolic models (GEMs) can facilitate metabolism-focused multi-omics
integrative analysis. Since Yeast8, the yeast-GEM of Saccharomyces cerevisiae, published …

Microbial communities are ubiquitous in nature and play an important role in ecology and
human health. Cross-feeding is thought to be core to microbial communities, though it …

Adaptive laboratory evolution experiments provide a controlled context in which the
dynamics of selection and adaptation can be followed in real-time at the single-nucleotide …