A promising therapeutic target for metabolic diseases: neuropeptide Y receptors in humans
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the
human central and peripheral nervous systems. It consists of 36 highly conserved amino …
human central and peripheral nervous systems. It consists of 36 highly conserved amino …
Recent progress in the genetics of common obesity
RJF Loos - British journal of clinical pharmacology, 2009 - Wiley Online Library
The genetic contribution to interindividual variation in common obesity has been estimated
at 40–70%. Yet, despite a relatively high heritability, the search for obesity susceptibility …
at 40–70%. Yet, despite a relatively high heritability, the search for obesity susceptibility …
DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
G Lettre, VG Sankaran, MAC Bezerra… - Proceedings of the …, 2008 - National Acad Sciences
Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable
phenotype characterized by severe pain crises, acute clinical events, and early mortality …
phenotype characterized by severe pain crises, acute clinical events, and early mortality …
Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes
F Abbatini, M Rizzello, G Casella, G Alessandri… - Surgical …, 2010 - Springer
Background This study aimed to compare the efficacy of laparoscopic sleeve gastrectomy
(SG) with that of laparoscopic gastric bypass (GBP) and laparoscopic adjustable gastric …
(SG) with that of laparoscopic gastric bypass (GBP) and laparoscopic adjustable gastric …
Using genome‐wide pathway analysis to unravel the etiology of complex diseases
CC Elbers, KR van Eijk, L Franke… - … Official Publication of …, 2009 - Wiley Online Library
Several genome‐wide association studies (GWAS) have been published on various
complex diseases. Although, new loci are found to be associated with these diseases, still …
complex diseases. Although, new loci are found to be associated with these diseases, still …
Genome-wide association of anthropometric traits in African-and African-derived populations
SJ Kang, CWK Chiang, CD Palmer… - Human molecular …, 2010 - academic.oup.com
Genome-wide association (GWA) studies have identified common variants that are
associated with a variety of traits and diseases, but most studies have been performed in …
associated with a variety of traits and diseases, but most studies have been performed in …
GLP-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance
N Matikainen, LH Bogl, A Hakkarainen… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Impaired incretin response represents an early and uniform defect in type 2
diabetes, but the contributions of genes and the environment are poorly characterized …
diabetes, but the contributions of genes and the environment are poorly characterized …
Neuropeptide Y is an angiogenic factor in cardiovascular regeneration
R Saraf, F Mahmood, R Amir, R Matyal - European journal of pharmacology, 2016 - Elsevier
In diabetic cardiomyopathy, there is altered angiogenic signaling and increased oxidative
stress. As a result, anti-angiogenic and pro-inflammatory pathways are activated. These …
stress. As a result, anti-angiogenic and pro-inflammatory pathways are activated. These …
Maternal genotype and gestational diabetes
Objective To determine whether genetic variants associated with glucose homeostasis are
associated with gestational diabetes (GDM). Study Design We genotyped 899 self-identified …
associated with gestational diabetes (GDM). Study Design We genotyped 899 self-identified …
Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain
Brain and gonadal hormones interplay controls metabolic and behavioral functions in a sex-
related manner. However, most translational neuroscience research related to animal …
related manner. However, most translational neuroscience research related to animal …