Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD
patients present with movement disorders, behavioral and psychiatric symptoms and …

The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …