Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

Structural chromosomal rearrangements result from different mechanisms of formation,
usually related to certain genomic architectural features that may lead to genetic instability …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or
diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which …

Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …

Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are
associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We …

This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its
evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei …