The WD40 domain is one of the most abundant and interacting domains in the eukaryotic
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …

Highlights•A LNA–DNA hybrid oligomer (miravirsen) is targeted to a host micro RNA instead
of the pathogen (hepatitis C virus)•Miravirsen demonstrates broad antiviral activity against …

The development of the human malaria parasite Plasmodium falciparum is controlled by
coordinated changes in gene expression throughout its complex life cycle, but the …

The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of
infected humans. During each replication cycle, a small proportion of parasites commits to …

We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene
natural products that is effective against drug-sensitive and drug-resistant Plasmodium …

Over the past decade, we have witnessed significant progresses in understanding gene
regulation in Apicomplexa including the human malaria parasite, Plasmodium falciparum …

Plasmodium falciparum, the human malaria parasite, infects two hosts and various cell
types, inducing distinct morphological and physiological changes in the parasite in response …

The virulence of Plasmodium falciparum, which causes the deadliest form of human malaria,
is attributed to its ability to evade the human immune response. These parasites “choose” to …

Twenty years since the publication of the Plasmodium falciparum and P. berghei genomes
one-third of their protein-coding genes still lack functional annotation. In the absence of …

Plasmodium falciparum is the most deadly human malarial parasite, responsible for an
estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal …