Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia
because of their high clinical efficacy. However, SGA treatment is associated with severe …

In numerous brain structures, insulin signaling modulates the homeostatic processes,
sensitivity to reward pathways, executive function, memory, and cognition. Through human …

Importance Cardiometabolic disorders often occur concomitantly with psychosis and
depression, contribute to high mortality rates, and are detectable from the onset of the …

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify
their risk factors and causative mechanisms due to their multifactorial nature, the limited …

Background Insulin resistance predisposes to cardiometabolic disorders, which are
commonly comorbid with schizophrenia and are key contributors to the significant excess …

Though the pathophysiology of schizophrenia remains poorly understood, altered brain
energy metabolism is increasingly implicated. Here, we conduct meta-analyses of the …

Background White matter (WM) microstructural abnormalities have been observed in
diabetes. However, evidence of prediabetes is currently lacking. This study aims to …

Abstract Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early
dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may …

Background: The causal evidence of the triglyceride–glucose (TyG) index, as well as the
joint exposure of higher glucose and triglyceride on the risk of cardio-cerebrovascular …

Nutritional psychiatry is a growing area of research, with several nutritional factors
implicated in the cause of psychiatric ill-health. However, nutritional research is highly …