Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess
immunomodulatory functions by interacting with other cells surrounding tumor, including T …

Non-homologous end joining (cNHEJ) is a major pathway to repair double-strand breaks
(DSBs) in DNA. Several core cNHEJ are involved in the progress of the repair such as KU70 …

Humans have evolved a series of DNA double-strand break (DSB) repair pathways to
efficiently and accurately rejoin nascently formed pairs of double-stranded DNA ends …

Non-homologous end-joining (NHEJ) is a DNA repair pathway required to detect, process,
and ligate DNA double-stranded breaks (DSBs) throughout the cell cycle. The NHEJ …

Developing B and T lymphocytes requires programmed DNA double-strand breaks followed
by the activation of the DNA damage response (DDR) pathway and DNA repair. It is …

Background During the process of generating diverse T and B cell receptor (TCR and BCR,
respectively) repertoires, double-strand DNA breaks are produced. Subsequently, these …

B lymphocyte development has two DNA recombination processes: V (D) J recombination of
the immunoglobulin (Igh) gene variable region, and class switching of the Igh constant …

Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells
that recognizes, processes and fixes DNA damage throughout the cell cycle and is …

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a rare
autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability …

Impaired DNA damage repair cascade can disrupt the lens transparency due to aging-
associated oxidative stress. The aim of study was to assess the association of 30 bp indel …