[HTML][HTML] The “CHEOPS” bundle for the management of Left Ventricular Diastolic Dysfunction in critically ill patients: an experts' opinion

F Sanfilippo, A Messina, S Scolletta, E Bignami… - … Critical Care & Pain …, 2023 - Elsevier
The impact of left ventricular (LV) diastolic dysfunction (DD) on the outcome of patients with
heart failure was established over three decades ago. Nevertheless, the relevance of LVDD …

What global diastolic function is, what it is not, and how to measure it

CS Chung, L Shmuylovich… - American Journal of …, 2015 - journals.physiology.org
Despite Leonardo da Vinci's observation (circa 1511) that “the atria or filling chambers
contract together while the pumping chambers or ventricles are relaxing and vice versa,” the …

Biomechanics of diastolic dysfunction: a one-dimensional computational modeling approach

K Kadry, S Pagoulatou, Q Mercier… - American Journal …, 2020 - journals.physiology.org
Diastolic dysfunction (DD) is a major component of heart failure with preserved ejection
fraction (HFpEF). Accordingly, a profound understanding of the underlying biomechanical …

Analysis of right ventricular myocardial stiffness and relaxation components in children and adolescents with pulmonary arterial hypertension

Y Hayabuchi, A Ono, Y Homma… - Journal of the American …, 2018 - Am Heart Assoc
Background The rate of left ventricular pressure decrease during isovolumic relaxation is
traditionally assessed algebraically via 2 empirical indices: the monoexponential and …

Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness

D Kamimura, T Suzuki, AL Furniss… - Journal of …, 2017 - journals.lww.com
Aim Osteoprotegerin (OPG) is associated with a poor prognosis in patients with heart failure
with preserved ejection fraction (HFpEF). OPG has also been associated with fibrosis and …

Alternative diastolic function models of ventricular longitudinal filling velocity are mathematically identical

D Bhagavan, WM Padovano… - American Journal of …, 2020 - journals.physiology.org
The spatiotemporal features of normal in vivo cardiac motion are well established.
Longitudinal velocity has become a focus of diastolic function (DF) characterization …

Cardiac amyloidosis shows decreased diastolic function as assessed by echocardiographic parameterized diastolic filling

K Salman, PA Cain, BT Fitzgerald, MG Sundqvist… - Ultrasound in Medicine …, 2017 - Elsevier
Cardiac amyloidosis is a rare but serious condition with poor survival. One of the early
findings by echocardiography is impaired diastolic function, even before the development of …

Quantifying Diastolic Function: From E-Waves as Triangles to Physiologic Contours via the 'Geometric Method'

M Golman, W Padovano, L Shmuylovich… - Cardiovascular …, 2018 - Springer
Conventional echocardiographic diastolic function (DF) assessment approximates
transmitral flow velocity contours (Doppler E-waves) as triangles, with peak (E peak) …

E-wave asymmetry elucidates diastolic ventricular stiffness-relaxation coupling: model-based prediction with in vivo validation

JM Amrute, D Zhang, WM Padovano… - American Journal of …, 2021 - journals.physiology.org
Load, chamber stiffness, and relaxation are the three established determinants of global
diastolic function (DF). Coupling of systolic stiffness and isovolumic relaxation has been …

[引用][C] Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function

M Arici, M Ferrandi, P Barassi, SC Hsu, E Torre… - … of Pharmacology and …, 2023 - ASPET