The 5-HT7 receptors (5-HT7Rs) are the most recent classified members of the serotonin
family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since …

An overview of pharmacophore models, developed for different subtypes of serotonin
receptors belonging to the GPCR family, is presented. Starting with early models for 5-HT1A …

Homology modeling is a reliable method of predicting the three-dimensional structures of
proteins that lack NMR or X-ray crystallographic data. It employs the assumption that a …

This study explores a new approach to pharmacophore screening involving the use of an
optimized linear combination of models instead of a single hypothesis. The implementation …

We describe the automated generation of libraries for predicting the geometric preferences
of druglike molecules. The libraries contain distributions of molecular dimensions based on …

The current study is focused on newly developed phenylpiperazine derivatives of aromatic
methylhydantoin differing in mutual positions of methyl and phenyl moieties. The new …

Anthrax lethal factor (LF) is a key virulence factor of anthrax lethal toxin. We screened a
chemolibrary of 10 000 drug-like molecules for their ability to inhibit LF and identified 18 …

Despite its remarkable importance in the arena of drug design, serotonin 1A receptor (5-
HT1A) has been elusive to the X-ray crystallography community. This lack of direct structural …

Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …

A series of 2-fluoro and 3-trifluoromethylphenylpiperazinylalkyl derivatives of 1 H-imidazo [2,
1-f] purine-2, 4 (3 H, 8 H)-dione (4–21) were synthesized and evaluated for their serotonin (5 …