Background Major depressive disorders have a significant impact on children and
adolescents, including on educational and vocational outcomes, interpersonal relationships …

There is a growing body of evidence pointing to the co-occurrence of cannabis use and
depression. There is also some evidence that the use of cannabis may lead to the onset of …

Cannabis is the most commonly used illicit substance in the United States. Rates of
cannabis use and cannabis use disorder (CUD) have increased in the past decade …

Background Depressive disorders are common in children and adolescents and, if left
untreated, are likely to recur in adulthood. Depression is highly debilitating, affecting …

Background Depressive disorders are common in young people and are associated with
significant negative impacts. Newer generation antidepressants, particularly selective …

Cannabis use disorder (CUD) commonly occurs and carries a notable economic and
functional burden at both individual and societal levels. While there are no clearly …

Substance use continues to contribute to significant morbidity and mortality in the United
States, for both women and men, more so than any other preventable health condition. To …

Rationale Cannabis use among people with mood disorders increased in recent years.
While comorbidity between cannabis use, cannabis use disorder (CUD), and mood …

Over 300,000 individuals enter treatment for cannabis-use disorders (CUDs) in the United
States annually. Cannabis withdrawal is associated with poor CUD-treatment outcomes, but …

Background Cannabis is the most prevalent illicit drug in the world. Demand for treatment of
cannabis use disorders is increasing. There are currently no pharmacotherapies approved …